Triterpene derivatives cholesterol acyltransferase inhibitors and methods of using same
US4987151A · kind A · utility
2Cited by
1References
24Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jun 19, 1989 |
| Grant date | Jan 22, 1991 |
| Priority date | — |
| Expiry date | Jun 19, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J63/008
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides a purified compound of the structure; ##STR1## wherein R may be palmitoyl or steroyl. The invention also provides compositions comprising an admixture of the foregoing palmitate and stearate esters. The invention also provides a compound of the structure: ##STR2## The invention further provides pharmaceutical compositions including the aforementioned compounds and compositions and methods of inhibiting the acyl CoA: cholesterol acyltransferase catalyzed conversion of cholesterol to cholesteryl esters.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.