Pharmacologically active phenylalkanoyl substituted imidazo (4,5-C) pyridines

US4988707A · kind A · utility

Assignee

• G.D. Searle LLC · US

Inventors

• Michael A. Stealey · Libertyville, US
• Richard M. Weier · Lake Bluff, US

Key dates

• Filing date: Sep 13, 1989
• Grant date: Jan 29, 1991
• Expiry date: Sep 13, 2009

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to substituted imidazopyridine dervatives having the following formula ##STR1## and isomers thereof; or a pharmaceutically acceptable acid addition salt thereof: wherein PA0 R.sub.1 and R.sub.2 are each independently selected from hydrogen; straight or branched chain alkyl of 1 to 15 carbon atoms; cycloalkyl of 3 to 8 carbon atoms; cycloalkyl which can be substituted once or more by alkyl of 1 to 6 carbon atoms; phenyl; phenyl which can be substituted once or more by alkyl of 1 to 6 carbon atoms or halogen; straight or branched alkenyl having 3 to 15 carbon atoms. PA0 y is phenyl or phenyl substituted once or more by alkyl of 1 to 6 carbon atoms; alkoxy wherein the alkyl is 1 to 6 carbon atoms; and halogen selected from the group consisting of bromo, fluoro or chloro. PA0 m is an integer from 0 to 5. PA0 n is an integer from 1 to 5. PA0 R.sub.3 is a group substituted at one or more of the 4, 6 or 7 positions of the pyridine ring said groups being independently selected from hydrogen, alkyl of 1 to 6 carbon atoms; halogen wherein the halogen is selected from bromo, fluoro, or chloro; or alkoxy wherein the alkyl is 1 to 6 carbon atoms; PA0 R.sub.4 is hydrogen o…