Diphenkylpropylamines for the therapy of heart disease
US4988730A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 21, 1989 |
| Grant date | Jan 29, 1991 |
| Priority date | — |
| Expiry date | Jul 21, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C233/43
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to novel diphenylpropylamine derivatives of the general formula (I). ##STR1## R.sup.1 stands for hydrogen or a methyl group; R.sup.2 stands for hydrogen, a methyl or n-decyl group; PA0 Z means a phenyl group substituted by R.sup.3, R.sup.4 and R.sup.5, wherein PA1 R.sup.3 means hydrogen, fluorine, chlorine or bromine, or a nitro, C.sub.1-12 alkyl, C.sub.1-4 alkoxy, phenoxy or benzyloxy group; PA1 R.sup.4 and R.sup.5 represent hydrogen, chlorine or a hydroxy, alkoxy, benzyloxy, acetamino or carboxy group; or PA1 R.sup.4 and R.sup.5 together form a methylendioxy group; PA0 or PA1 Z may stand for a 4-methoxynaphtyl or 4-ethoxy-naphthyl group; and PA1 R.sup.6 stands for hydrogen or fluorine, with the proviso that each of R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.6 cannot simultaneously stand for hydrogen, as well as their physiologically acceptable acid addition salts. The invention also relates to a process for the preparation of these compounds and to the pharmaceutical compositions containing these compounds. The compounds of the general formula (I) can preferably be used for the treatment of cardiovascular diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.