Method of making lipid tubules by a cooling process
US4990291A · kind A · utility
35Cited by
5References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 29, 1988 |
| Grant date | Feb 5, 1991 |
| Priority date | — |
| Expiry date | Feb 29, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/1274
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Diacetylinic phosophocholines have distinctly different endothermic and exothermic transition temperatures. Lipid tubules are formed by hydrating a diacetylinic phosphocholine at a temperature above its endothermic transition temperature. The hydrated lipid is then cooled slowly to a formation temperature 1.degree. to 10.degree. C. below the exothermic transition temperature to form tubule structures. The tubules structures can be polymerized to form permanent tubules. The tubules can be used in the same manner as a liposome vesicle or they can be metal coated for a variety of applications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.