Use of vinyl alcohol homopolymer and copolymers for tableting active materials

US4990335A · kind A · utility

Assignee

• E.I. DU PONT DE NEMOURS AND COMPANY · US

Inventors

• Linda R. Bateman · Breckenridge, US
• Robert C. Di Luccio · Wilmington, US
• Clare Stewart · Wilmington, US
• Donna Lynn Visioli · North Wales, US
• David P. Beach-Coffin · Lindenhurst, US

Key dates

• Filing date: May 12, 1988
• Grant date: Feb 5, 1991
• Expiry date: May 12, 2008

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/2027
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Method of making tablets for active ingredient delivery by compressing a mixture of active ingredient and granular, high viscosity, fully hydrolyzed polyvinyl alcohol or copolymer of vinyl alcohol with methyl acrylate or methyl methacrylate. By use of a crystalline, heat treated polymer, a tablet providing quick active ingredient release is obtained. By using an amorphous, non-heat treated polymer a tablet providing prolonged active ingredient release is obtained. By using blends of crystalline and amorphous polymers, tablets having a range of active ingredient release characteristics can be obtained. The granular, high viscosity, fully hydrolyzed polymers provide flowability, compressibility and processing versatility advantages over conventional tablet binders.