Process for the preparation of unsymmetric biaryl compounds

US4990647A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Thomas Himmler · Odenthal, DE
• Rudolf Braden

Key dates

• Filing date: Apr 24, 1989
• Grant date: Feb 5, 1991
• Expiry date: Apr 24, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C41/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Unsymmetric biaryl compounds are prepared by coupling two different halogenoaromatics by reaction with a metal and carrying out the reaction in the presence of catalytic amounts of a nickel compound, a promoter and a phosphorus-containing ligand.