Optically active .alpha.-amino aldehydes, process for the preparation thereof, and the use thereof for the stereoselective preparation of optically active .beta.-amino alcohols

US4990669A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Manfred T. Reetz · Mülheim an der Ruhr, DE
• Mark Wilhelm Drewes · Langenfeld, DE

Key dates

• Filing date: Mar 23, 1988
• Grant date: Feb 5, 1991
• Expiry date: Mar 23, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C255/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to new optically active .alpha.-amino aldehydes of the formulae ##STR1## in which R.sub.1 represents an optionally substituted alkyl, alkenyl, aralkyl or aryl radical, and PA0 R.sub.2 and R.sub.3, independently of one another, denote an optionally substituted alkyl, alkenyl, cycloalkyl or aralkyl group, together form an optionally substituted phenylene-(1,2)-bis-methylene radical, or R.sub.2 is an optionally substituted, alkyl, cycloalkyl or aralkyl radical, and R.sub.3 forms together with R.sub.1 a 1,3-propylene radical. a process for the preparation thereof, and the use thereof for the stereoselective preparation of optically active .beta.-amino alcohols.