Substituted pyrroles

US4992462A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Walter Hubsch · Wuppertal, DE
• Rolf Angerbauer · Wuppertal, DE
• Peter Fey · Wuppertal, DE
• Hilmar Bischoff · Wuppertal, DE
• Dieter Petzinna · Mülheim an der Ruhr, DE
• Delf Schmidt · Wuppertal, DE
• Gunter Thomas · Arese, IT

Key dates

• Filing date: Apr 7, 1988
• Grant date: Feb 12, 1991
• Expiry date: Apr 7, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

For inhibiting 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase, the novel substituted pyrroles of the formula ##STR1## in which R.sup.1 is optionally alkyl or cycloalkyl, PA1 R.sup.2 and R.sup.3 each is optionally substituted aryl or heteroaryl, PA1 R.sup.4 is H or an organic radical, PA1 X is --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, PA1 A is ##STR2## R.sup.7 is H or alkyl, and R.sup.8 is H or an ester or cation radical. Novel intermediates therefor are also provided.