Preparation of oxiranes

US4992565A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Karl H. Mohrmann · Bensberg, DE
• Wolf Reiser · Wuppertal, DE
• Siegfried W. Linke · Wuppertal, DE
• Rudolf Zerbes · Wuppertal, DE

Key dates

• Filing date: Apr 12, 1990
• Grant date: Feb 12, 1991
• Expiry date: Apr 12, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D303/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of an oxirane of the formula ##STR1## in which Y is chlorine or phenyl, PA1 X is oxygen or CH.sub.2, and PA1 Z is hydrogen or halogen, comprising reacting dimethyl sulphide with methyl bromide in the presence of an inert organic diluent thereby to produce trimethylsulphonium bromide of the formula EQU (CH.sub.3).sub.3 S.sup..sym. Br.sup..crclbar. and reacting the trimethylsulphonium bromide with a ketone of the formula ##STR2## in the presence of a base and in the presence of an inert organic diluent, at a temperature between about 0.degree. C. and 60.degree. C. The end products are produced in high yield and are known intermediates for known fungicides.