Extended shelf life platelet preparations and process for preparing the same
US4994367A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 7, 1988 |
| Grant date | Feb 19, 1991 |
| Priority date | — |
| Expiry date | Oct 7, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01N1/126
- WIPO fieldBasic materials chemistry
- WIPO sectorChemistry
Abstract
A first aspect of the present invention is a blood platelet preparation comprising blood platelets, an adenylate cyclase stimulator, a phosphodiesterase inhibitor, a thrombin inhibitor, and a plasmin inhibitor. A second aspect of the present invention is a plasma-free platelet storage medium containing dextrose, sodium citrate, sodium bicarbonate, and a platelet activation inhibitor, with a preferred platelet activation inhibitor comprising an adenylate cyclase stimulator in combination with a phosphodiesterase inhibitor. A third aspect of the present invention is a process for producing a plasma-free platelet preparation comprising producing platelet-rich plasma (PRP) from whole blood, adding a platelet activation inhibitor thereto, centrifuging the PRP to deposit the platelets on the bottom of the centrifuge container, removing the platelet-free plasma supernatant therefrom and adding a plasma-free liquid platelet storage medium thereto. A preferred platelet activation inhibitor for the process comprises an adenylate cyclase stimulator in combination with a phosphodiesterase inhibitor. A preferred adenylate cyclase stimulator is Prostaglandin El, a preferred phosphodiesterase inh…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.