Alkyl- or aryl-aminoalkoxy-benzene-sulfonyl indoles

US4994474A · kind A · utility

Assignee

• Sanofi · FR

Inventors

• Jean Gubin · Brussels, BE
• Pierre Chatelain · Brussels, BE
• Henri Inion · Wemmel, BE

Key dates

• Filing date: Feb 6, 1989
• Grant date: Feb 19, 1991
• Expiry date: Feb 6, 2009

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to aminoalkoxyphenyl derivatives of formula: ##STR1## and its N-oxide and pharmaceutically acceptable salts, in which: B represents a--S--, --SO-- or --SO.sub.2 -- group, PA1 R.sub.1 and R.sub.2, which are identical or different, each denote hydrogen, a methyl or ethyl radial or a halogen atom, PA1 A denotes a straight-or branched-alkylene radical having from 2 to 5 carbon atoms or a 2-hydroxypropylene radial in which the hydroxy is optionally substituted by a lower alkyl radical, PA1 R.sub.3 denotes an alkkyl radical or a radical of formula: EQU --Alk--Ar PA1 in which Alk denotes a single bond or a linear- or branched-alkylene radical having from 1 to 5 carbon atoms and Ar denotes a pyridyl, phenyl, 2,3-methylenedioxyphenyl or 3,4-methylenedioxyphenyl radical or a phenyl group substituted with one or more substituents, which may be identical or different, selected from halogen atoms, lower alkyl group or lower alkoxy groups, PA1 R.sub.11 denotes hydrogen or a lower alkyl, phenyl, diphenylmethyl, benzyl or halogenobenzyl radical, PA1 R.sub.4 denotes hydrogen or an alkyl radical, or R.sub.3 and R.sub.4 when taken together denote an alkylene or alkenylen…