Human basic fibroblast growth factor
US4994559A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Jan 26, 1989 |
| Grant date | Feb 19, 1991 |
| Priority date | — |
| Expiry date | Jan 26, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/851
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An angiogenic factor is disclosed which is a purified, single-polypeptide-chain protein having at least one active site possessing an activity selected from the group consisting of mitogenic activity, chemotactic activity, the ability to stimulate protease synthesis and combinations thereof. This angiogenic factor exhibits substantial homology to and is immunologically equivalent to the native angiogenic factor isolatable from human placental tissues. The amino acid sequence of this angiogenic factor is also disclosed. In addition, a method for isolation of the purified angiogenic factor from human placental tissues is set forth. Pharmaceutical preparations incorporating this angiogenic factor are described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.