5,6-dihydro-4H-1,3-oxa(or thia)zine derivatives, their preparation and compositions containing them
US4994569A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 1, 1989 |
| Grant date | Feb 19, 1991 |
| Priority date | — |
| Expiry date | Nov 1, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of formula: ##STR1## in which R.sub.1 denotes 2-indolyl, 2-thienyl, 3-furyl, naphthyl, phenyl, or phenyl substituted with one or two halogen atoms, with alkoxy, alkyl, nitro, acylamino, alkylthio, acyl, trifluoromethoxy, morpholino, piperidino, amino, mono- or dialkylamino or, at the 3- and 4-positions, with methylenedioxy PA1 R.sub.2 denotes phenyl or phenyl substituted with one or two halogen atoms, with one or two alkyl radicals, with alkoxy, nitro, trifluoromethyl or hydroxy or, at the 3- and 4-positions, with methylenedioxy and PA1 either X denotes oxygen and PA1 R.sub.3 denotes phenyl R.sub.4, R.sub.5 and R.sub.6 denote hydrogen, or PA1 R.sub.3 and R.sub.4 denote hydrogen, R.sub.5 denotes hydrogen or methyl and R.sub.6 denotes phenyl or one of R.sub.3 and R.sub.4 denotes methyl and the other hydrogen, R.sub.5 denotes hydrogen and R.sub.6 denotes phenyl, PA1 or X denotes sulphur, R.sub.3 denotes phenyl and R.sub.4, R.sub.5 and R.sub.6 denote hydrogen; the said acyl, alkyl and alkoxy radicals and acyl, alkyl and alkoxy portions containing 1 to 4 carbon atoms each in a straight or branched chain; and their salts are useful in the treatment and prevention of disorders i…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.