Process for the preparation of optically active secondary arylamines
US4994615A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 29, 1987 |
| Grant date | Feb 19, 1991 |
| Priority date | — |
| Expiry date | Jul 29, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C209/52
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Asymmetric hydrogenation of prochiral N-arylketimines to give optically active secondary amines at a temperature of -20.degree. to 80.degree. C., a hydrogen pressure of 10.sup.5 to 6.10.sup.6 Pa with the addition of catalytic amounts of an iridium compound of the formula III or IIIa EQU [XIrYZ] (III) EQU or EQU [XIrY.sup..sym. A.sup..crclbar. (IIIa) in which X is two olefin ligands or one diene ligand, Y is a chiral diphosphine, the secondary phosphine groups of which are linked by 2-4 C atoms and which, together with the Ir atom, forms a 5-, or 6- or 7-ring, or Y is a chiral diphosphinite, the phosphinite groups of which are linked via 2 C atoms and which together with the Ir atom forms a 7-ring, Z is Cl, Br or I and A.sup.63 is the anion of an oxygen acid or complex acid, and if appropriate with the addition of an ammonium or alkali metal chloride, bromide or iodide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.