Optical resolution of racemic alcohols
US4996158A · kind A · utility
19Cited by
0References
7Claims
0Family size
Inventors
Key dates
| Filing date | Dec 21, 1988 |
| Grant date | Feb 26, 1991 |
| Priority date | — |
| Expiry date | Dec 21, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/07
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A racemic alcohol is subjected to the optical resolution by irreversibly esterifying one of the two antipodes of the racemic alcohol with an acid anhydride or enol ester of a carboxylic acid in a organic solvent in the presence of a hydrolase. This optical resolution uses a non-aqueous organic solvent in which the hydrolase is insoluble and involves an irreversible esterification, thus permitting an efficient optical resolution and improving recovery and re-usability of the hydrolase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.