Imidazolidine derivatives as immunosuppressives

US4996219A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Christos Tsaklakidis · Weinheim, DE
• Elmar Bosies · Weinheim, DE
• Michael Schultz · Mannheim, DE
• Rainer Haag · Berlin, DE
• Dieter Herrmann · Kirchzarten, DE
• Wulf Pahlke · Bensheim, DE

Key dates

• Filing date: Dec 13, 1989
• Grant date: Feb 26, 1991
• Expiry date: Dec 13, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of the general formulae: ##STR1## wherein R.sub.1 and R.sub.2, which can be the same or different, are hydrogen atoms or C.sub.1 -C.sub.5 -alkyl radicals, C.sub.3 -C.sub.5 -alkenyl radicals or phenyl radicals or, together with the carbon atom to which they are attached, form a saturated or unsaturated C.sub.3 -C.sub.7 ring, R.sub.3 and R.sub.4, which can be the same or different, are hydrogen atoms, straight-chained or branched C.sub.1 -C.sub.10 -alkyl radicals, straight-chained or branched C.sub.3 -C.sub.7 -alkenyl radicals, C.sub.3 -C.sub.7 -cycloalkyl radicals, C.sub.3 -C.sub.7 -cycloalkenyl radicals, phenyl, arylalkyl or hetarylalkyl radicals, R.sub.5 is a hydrogen atom or a lower alkyl radical and X is an oxygen or sulphur atom or an imino group. The present invention also provides processes for the preparation of these compounds, as well as pharmaceutical compositions with immunosuppressive action containing them.