Histamine derivatives as immune modulators
US4996221A · kind A · utility
6Cited by
6References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 13, 1987 |
| Grant date | Feb 26, 1991 |
| Priority date | — |
| Expiry date | Jan 13, 2007 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/807
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Histamine derivatives are disclosed which find use as effect and tissue-specific immune modulators. Specifically, the primary terminal nitrogen in histamine is derivatized to introduce a variable length side chain having 0 to 1 branch of from 1 to 3 carbons; 0 to 2 non-oxo-carbonyl groups; 0 to 4 heteroatoms, other than the non-oxo carbonyl oxygen; 0 to 1 aryl or alkyl-aryl group; and 0 to 1 functionally bound amino acid, polypeptide, or protein or derivative thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.