Tri-phenyl alkane derivatives and their oestrogenic, anti-oestrogenic and progestanic uses
US4996225A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 12, 1989 |
| Grant date | Feb 26, 1991 |
| Priority date | — |
| Expiry date | Oct 12, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D309/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
##STR1## wherein n is 0 to 4, R.sub.1 and R.sub.2, which can be the same or different, are H or OH; R.sub.3 is --O--(CH.sub.2).sub.m --CH.sub.2 --NR.sub.6 R.sub.7 wherein m is 1 or 2, R.sub.6 and R.sub.7, which can be the same or different, are H or an alkyl group of 1 to 4 carbon atoms, or --NR.sub.6 R.sub.7 can form a pyrrolidinyl group; and R.sub.4 is halogen, and their non-toxic pharmaceutically acceptable salts and phenolic esters of aliphatic or aromatic carboxylic acids, acid anhydrides or acid chlorides thereof are disclosed. These compounds exhibit valuable pharmacological properties as estrogenic, anti-estrogenic, and progestanic agents. They show activity against oestrogen-dependent tumors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.