Method for preparing pertussis toxin toxoid using HcHo and amino acids
US4996299A · kind A · utility
4Cited by
6References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 28, 1989 |
| Grant date | Feb 26, 1991 |
| Priority date | — |
| Expiry date | Nov 28, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/825
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a method for preparing pertussis toxin toxoid by a treatment pertussis toxin with formaldehyde, which comprises carrying out said treatment in the presence of lysine or glycine in combination with N-acetyltriptophan. The resultant toxoid does not exhibit toxicity reversion, thereby making the toxoid highly suitable for use in pertussis vaccines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.