Optical indicator coumarins and methods for their preparation and use
US4996332A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 13, 1988 |
| Grant date | Feb 26, 1991 |
| Priority date | — |
| Expiry date | Jun 13, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/28
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Optical indicator chalcogen (selenide or sulfide) compounds responsive to oxidants, e.g., hydrogen peroxide, and methods for preparing and using such indicators. Upon oxidation the resulting intermediate undergoes spontaneous elimination of the chalcogen residue to yield a signal compound which provides an optical signal such as fluorescence. Preferred fluorogenic indicator compounds are 3-chalcogen-3,4-dihydrocoumarin derivatives and 3-chalcogen-3,4-dihydro-2-quinolone derivatives. Such indicator compounds provide highly fluorescent products upon oxidation by hydrogen peroxide and are useful in analytical systems which generate hydrogen peroxide in response to the analyte under determination.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.