Method for making uniformly-sized particles from insoluble compounds
US4997454A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 26, 1989 |
| Grant date | Mar 5, 1991 |
| Priority date | — |
| Expiry date | Apr 26, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K49/0476
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention involves a method for making uniformly sized particles from solid compounds. First, a suitable solid compound is dissolved in a suitable solvent. Then, a precipitating liquid is infused, precipitating non-aggregated particles with substantially uniform mean diameter. The particles are then separated from the solvent. Depending on the solid compound and the desired particle size, the parameters of temperature, ratio of non-solvent to solvent, infusion rate, stir rate, and volume can be varied according to the invention. The precipitating liquid may be aqueous or non-aqueous, depending upon the relative solubility of the compound and the desired suspending vehicle.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.