pH-sensitive immunoconjugates and methods for their use in tumor therapy
US4997913A · kind A · utility
39Cited by
5References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 12, 1987 |
| Grant date | Mar 5, 1991 |
| Priority date | — |
| Expiry date | May 12, 2007 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/812
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel pH-sensitive immunoconjugates which dissociate in low-pH tumor tissue, comprising a chemotherapeutic agent and an antibody reactive with a tumor-associated antigen are described. The chemotherapeutic agent is coupled to the antibody by a link which is unstable in low pH. The link may comprise a spacer consisting of a polyamino acid. Representative antibodies for use in these immunoconjugates include monoclonal antibodies which are not internalized by tumor cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.