Trisubstituted amines, pharmacologically acceptable salts thereof and pharmaceutical compositions containing them

US4999361A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Christos Tsaklakidis · Weinheim, DE
• Herbert Leinert · Heppenheim, DE
• Peter C. Freund · Ketsch, DE

Key dates

• Filing date: Feb 27, 1989
• Grant date: Mar 12, 1991
• Expiry date: Feb 27, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/42
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of the general formula ##STR1## wherein R.sub.1 is a hydrogen atom, a straight-chained or branched C.sub.1 -C.sub.12 -alkyl radical, a C.sub.3 -C.sub.7 -cycloalkyl radical, a straight-chained or branched C.sub.2 -C.sub.12 -alkenyl radical or an unsubstituted or substituted C.sub.3 -C.sub.7 -mono- or bicycloalkenyl radical, an unsubstituted or singly or multiple substituted monocyclic aromatic or heteroaromatic radical, R.sub.2 and R.sub.3, which can be the same or different, are straight-chained, branched, saturated or unsaturated C.sub.1 -C.sub.6 -aliphatic radicals or, together with the nitrogen atom to which they are attached, form a saturated or unsaturated ring which can contain further heteroatoms and can optionally be substituted by a lower alkyl radical, a lower alkoxy radical or an oxygen atom, R.sub.4 is an unsubstituted or singly or multiple substituted monocyclic aromatic radical, an unsubstituted or substituted five- or six-membered heteroaromatic ring, R.sub.5 is a hydrogen atom, a cyano radical, a --CO--OR.sub.7 radical, an unsubstituted or a singly or multiple substituted monocyclic aromatic radical or an unsubstituted or sub…