Process for preparing quinoline aldehyde and ketone derivatives
US4999431A · kind A · utility
0Cited by
5References
1Claims
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Assignee
Inventors
Key dates
| Filing date | Feb 23, 1990 |
| Grant date | Mar 12, 1991 |
| Priority date | — |
| Expiry date | Feb 23, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.