Truncated human IL-1 cDNA sequences which encode biologically-active human IL-1 proteins
US5001057A · kind A · utility
21Cited by
1References
7Claims
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Key dates
| Filing date | Apr 21, 1988 |
| Grant date | Mar 19, 1991 |
| Priority date | — |
| Expiry date | Apr 21, 2008 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/141
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The subject invention concerns truncated human IL-1 cDNA sequences which encode biologically-active novel human IL-1 proteins. These truncated human IL-1 cDNA sequences can be obtained by genetic engineering procedures using a clone of human IL-1 cDNA, having the accession number NRRL B-15770, as a starting material. The truncated human IL-1 cDNA sequences of the subject invention are contained in specified plasmids whose constructions are described in detail. Biologically-active human IL-1 proteins are useful to induce the production of IL-2 by activated T-cells. They also act on B-cells and NK-cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.