Di- or tripeptide renin inhibitors containing lactam conformational restriction in ACHPA
US5001113A · kind A · utility
5Cited by
1References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 7, 1990 |
| Grant date | Mar 19, 1991 |
| Priority date | — |
| Expiry date | Mar 7, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0227
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Enzyme di- or tripeptides of the formula: ##STR1## and analogs thereof which inhibit renin and are useful for treating various forms of renin-associated hypertension, hyperaldosteronism and congestive heart failure; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension, hyperaldosteronism or congestive heart failure or of establishing renin as a causative factor in these problems which employ these novel peptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.