Photochemotherapic method of treating psoriasis by using methylangelicin compounds
US5001147A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 16, 1988 |
| Grant date | Mar 19, 1991 |
| Priority date | — |
| Expiry date | May 16, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D311/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The alkylangelicins according to the invention are obtained starting from an umbelliferone, in which the 6-position is already substituted by an alkyl group; in such a way the 7-allyloxy or 7-acyloxy umbelliferone intermediates can form by transposition of the allyl or acyl group only the 8-allyl and 8-acyl derivatives, and therefore the presence, even in traces, of psoralens is absolutely excluded in the subsequent synthetic steps. The 6-alkylangelicins thus obtained are particularly usable for the photochemotherapy of psoriasys and of other skin diseases characterized by cellular hyperproliferation, as well as for the photochemotherapy of vitiligo and of alopecia aerata.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.