Optical resolution of DL-3-acylthio-2-methylpropanoic acid
US5001251A · kind A · utility
11Cited by
5References
4Claims
0Family size
Assignee
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Key dates
| Filing date | Jan 15, 1988 |
| Grant date | Mar 19, 1991 |
| Priority date | — |
| Expiry date | Jan 15, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C211/30
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An optically active amine compound and a method for preparing same are provided which compound has the structure ##STR1## in the form of its R-(+) enantiomer or S-(-) enantiomer, wherein R and R.sup.1 are independently H, lower alkyl or halogen, R.sup.2 is H or lower alkyl and R.sup.3 is lower alkyl, the optically active amine is useful in the optical resolution of DL-3-acylthio-2-methylpropanoic acid wherein acyl is acetyl or benzoyl. The optically active D-(+)-3-acylthio-2-methylpropanoic acids are used as intermediated for preparing antihypertensive agents, such as captopril.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.