Specific ligands for estrogen and progestagen steroid hormone receptors, application and intermediate synthesis products
US5002753A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 18, 1989 |
| Grant date | Mar 26, 1991 |
| Priority date | — |
| Expiry date | Oct 18, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J51/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to specific ligands for estrogen or progestagen steroid hormone receptors which have the formula ##STR1## in which X denotes a vinyl group substituted by a radioactive or nonradioactive halogen on the double bond according to a Z isomerism, and PA0 Y denotes either a hydroxyl group, in which case the ring to which it is attached is an aromatic ring, or a ketone functional group, in which case it is conjugated with a double bond at C.sub.4 -C.sub.5. An application of the ligands according to the invention is the targeted therapy and/or medical imagery, especially of cancer. However, these ligands can also be employed in the quantitative determination of said hormone receptors. However, the labeled ligands according to the invention are of very particular interest in the case of the targeted radiotherapy of cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.