Use of ginkgolides to prevent reperfusion injury in organ transplantation

US5002965A · kind A · utility

Assignee

• Société de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S) SAS · FR

Inventors

• Peter W. Ramwell · McLean, US
• Marie Foegh · Cresskill, US

Key dates

• Filing date: May 9, 1989
• Grant date: Mar 26, 1991
• Expiry date: May 9, 2009

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K36/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A living tissue or living cell preservation solution comprising an effective amount of a ginkgolide to reduce reperfusion injury in living tissue which has been stored therein and a substance or mixture or substances present in an amount sufficient to produce an osmotic pressure in said solution approximately equal to the osmotic pressure or mammalian cell and a method for preventing or reducing reperfusion injury in transplanted mammalian organs, which comprises contacting an organ prior to reperfusion with an effective amount of a ginkgolide to reduce reperfusion injury in said organ.