Method for the preparation of monohydrate
US5003064A · kind A · utility
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9Claims
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Key dates
| Filing date | Feb 23, 1989 |
| Grant date | Mar 26, 1991 |
| Priority date | — |
| Expiry date | Feb 23, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D501/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Cefadroxil monohydrate is prepared by solubilizing 7-[D-(-)-.alpha.-benzyloxycarbonylamino-.alpha.-(p-hydroxyphenyl)acetamido ]-3-methyl-3-cephem-4-carboxylic acid by silylation or by salification in an organic solvent, subjecting the solubilized acid in the solvent to catalytic hydrogenation, separating the catalyst from the solution, and adding water to the solution at a pH of about 4 to precipitate cefadroxil monohydrate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.