Chichibabin reaction
US5003069A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 26, 1989 |
| Grant date | Mar 26, 1991 |
| Priority date | — |
| Expiry date | Jul 26, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D215/38
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
In a Chichibabin amination of a nitrogen-containing heterocyclic base by sodamide in an organic solvent, the improvement comprising conducting the reaction under pressure of at least about 50 psi in the gas phase above the reaction mixture and adding ammonia to the mixture sufficient to produce a partial pressure of ammonia of at least about 5 psi in the gas phase. Preferred temperature and pressure ranges are disclosed, as are catalysts and other preferred steps for practicing the reaction. Significant results are obtained including improved and changed yields from those classically expected in Chichibabin aminations, including new compositions of matter in at least three cases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.