Low-melting moldable pharmaceutical excipient and dosage forms prepared therewith
US5004601A · kind A · utility
144Cited by
7References
7Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Oct 31, 1988 |
| Grant date | Apr 2, 1991 |
| Priority date | — |
| Expiry date | Oct 31, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/2031
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An exicipient for a pharmaceutical compound which melts at body temperature but will not spontaneously deform at higher temperatures encountered in shipment and storage comprises: ______________________________________ Low MW Polyethylene glycol 75-90% (M.P. about 37.degree. C.) Medium to high MW polyethylene glycol 0-4% Long chain saturated carboxylic acid 0-4% Polyethylene oxide 0-4% (MW 100,000-5,000,000) Colloidal silica 10-20%. ______________________________________ The excipient is particularly advantageous for the preparation of dosage forms for buccal administration of pharmaceutical compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.