Cationized antibodies for delivery through the blood-brain barrier
US5004697A · kind A · utility
214Cited by
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9Claims
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Key dates
| Filing date | Aug 17, 1987 |
| Grant date | Apr 2, 1991 |
| Priority date | — |
| Expiry date | Aug 17, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The rate of trancytosis of antibodies across the blood-brain barrier is increased by cationizing the antibodies to provide cationized antibodies having an isoelectric point of between about 8.0 to 11.0. The increased rates of transport across the blood-brain barrier makes such cationized antibodies useful for both neurodiagnostic and neuropharmaceutical purposes. Methods for preparing such cationized antibodies are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.