Method for increasing tumor sensitivity to chemotherapy
US5005588A · kind A · utility
22Cited by
4References
14Claims
0Family size
Inventor
Key dates
| Filing date | Oct 13, 1989 |
| Grant date | Apr 9, 1991 |
| Priority date | — |
| Expiry date | Oct 13, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Drug-resistant tumor cells are rendered drug-sensitive by administering to the tumor cells a pump-affecting compound which suppresses the pumping action of P-glycoprotein on the tumor cells. In the case where the tumor cells have higher .beta.-glucuronidase activity than that of the surrounding tissues, the pump-affecting compound is in the form of a .beta.-D-glucuronide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.