Direct tableting auxiliary
US5006345A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Dec 12, 1988 |
| Grant date | Apr 9, 1991 |
| Priority date | — |
| Expiry date | Dec 12, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/2095
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Direct tableting auxiliaries essentially consists of PA1 (A) from 88 to 96% by weight of pulverulent carrier conventionally used for the preparation of tablets and consisting of lactose, or lactose together with not more than the same amount of another carrier, PA1 (B) from 2 to 6% by weight of polyvinylpyrrolidone having a K value of from 20 to 40, and PA1 (C) from 2 to 10% by weight of crosslinked, insoluble polyvinylpyrrolidone, all percentages being based on the direct tableting auxiliary, and are obtained by spray drying, spray granulation or wet granulation. The novel direct tableting auxiliaries exhibit good flow and good compressibility under low pressure, and the tablets produced using the said auxiliaries possess excellent disintegration properties coupled with great hardness and low abrasion.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.