Pharmaceuticals, phosphorus-containing 2-isoxazolines and isoxazoles contained therein

US5006515A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Wilfried Schwab · Altentreptow, DE
• Robert R. Bartlett · Darmstadt, DE
• Ulrich Gebert · Königstein, DE
• Hans-Ulrich Schorlemmer · Marburg, DE
• Gerhard Dickneite · Marburg, DE
• Hans-Harald Sedlacek · Marburg, DE

Key dates

• Filing date: Oct 26, 1988
• Grant date: Apr 9, 1991
• Expiry date: Oct 26, 2008

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pharmaceuticals containing or composed of at least one compound of the formula I and/or one of its physiologically tolerated salts where appropriate, where the compounds of the formula I can, where appropriate, be in the form of pure stereoisomers or mixtures thereof; formula I is: ##STR1## in which R.sup.1 =organic radical or halogen, PA0 A=C,C single or C,C double bond, PA0 n=0, 1 or 2, and ##STR2## R.sup.2 and R.sup.3 =H or optionally substituted aliphatic radical. The pharmaceuticals are suitable for the prophylaxis and/or treatment of diseases of the immune system, especially of tumors, infections and/or autoimmune diseases of the human or animal body and for use as adjuvants for vaccines. Some of the compounds of the formula I are new; the compounds can be prepared by special processes.