Condensed diazepinones, processes for preparing them and pharmaceutical compositions containing these compounds

US5006522A · kind A · utility

Assignee

• Karl Thomae GmbH · DE

Inventors

• Wolfhard Engel
• Wolfgang Eberlein · Biberach, DE
• Gerhard Mihm · Biberach, DE
• Gunther Trummlitz · Biberach, DE
• Norbert Mayer · Gersthofen, DE
• Adriaan De Jonge · Driebergen-Rijsenburg, NL

Key dates

• Filing date: May 30, 1989
• Grant date: Apr 9, 1991
• Expiry date: May 30, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel condensed diazepinone of general formula I are described, ##STR1## wherein B represents one of the divalent groups ##STR2## and X.sup.1, X.sup.2, A.sup.1, A.sup.2 and R.sup.1 to R.sup.10 are as defined in herein useful as vagal pacemakers for treating bradycardia and bradyarrhythmia. The novel diazepinones also have spasmolytic properties on peripheral organs, antiemetic properties and are capable of promoting cerebral blood flow.