Imidazole derivatives and pharmaceutical use thereof
US5006544A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 12, 1989 |
| Grant date | Apr 9, 1991 |
| Priority date | — |
| Expiry date | Oct 12, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D409/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides imidazole derivatives of the general formula (I) ##STR1## wherein Im representes an imidazolyl group of the formula: ##STR2## and one of the groups represented by R.sup.3, R.sup.4 and R.sup.5 is a hydrogen atom, or a C.sub.1-6 alkyl, C.sub.3-7 cycoalkyl, C.sub.3-6 alkenyl, phenyl or phenylC.sub.1-3 alkyl group, and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C.sub.1-6 alkyl group; PA1 R.sup.1 and R.sup.2 each represent a hydrogen atom, or together with the carbon atoms to which they are attached form a phenyl ring; PA1 X represents an oxygen or a sulphur atom, or a group NR.sup.6, wherein R.sup.6 represents a C.sub.1-6 alkyl group; PA1 Z--Y represents the group CH--CH.sub.2 or C.dbd.CH; and physiologically acceptable salts and solvates thereof. The compounds of formula (I) are potent and selective antagonists of 5-hydroxytryptamine at 5-HT.sub.3 receptors and are useful, for example, in the treatment of psychotic disorders, anxiety and nausea and vomiting.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.