Patent · US Expired

Process for the preparation of tetrahydrofolates

US5006655A · kind A · utility

28Cited by

2References

16Claims

0Family size

Assignee

EPROVA AG · CH

Inventors

Hans Muller · Kirkland, US
Martin Ulmann · Dachsen, CH
Josef Conti · Schaffhausen, CH
Gunter Murdel · Tengen, DE

Key dates

Filing date	Jun 29, 1989
Grant date	Apr 9, 1991
Priority date	—
Expiry date	Jun 29, 2009

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D475/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

For the preparation of 5,10-methenyl-(6R)-, 5-formyl-(6S)- or 5-methyl-(6S)-tetrahydrofolic acid or salts thereof, 5,10-methenyl-(6R,S)-tetrahydrofolic acid, the inner salt thereof or one of the salts thereof with strong acids is subjected to diastereomer separation by fractional crystallization and, if desired, the resulting 5,10-methenyl-(6R)-tetrahydrofolic acid is converted by treatment with a hydrolyzing agent into 5-formyl-(6S)-tetrahydrofolic acid or by treatment with a reducing agent into 5-methyl-(6S)-tetrahydrofolic acid, and the resulting free acid may be converted into one of its salts by treatment with a base.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.