Salts of ranitidine and complexes of bismuth with carboxylic acids, and pharmaceutical compositions thereof
US5008256A · kind A · utility
16Cited by
1References
17Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jul 17, 1989 |
| Grant date | Apr 16, 1991 |
| Priority date | — |
| Expiry date | Jul 17, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P29/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to salts formed between ranitidine and a complex of bismuth with a carboxylic acid, and solvates of such salts. Examples of suitable carboxylic acids are citric acid, tartaric acid and agaricic acid. The salts are useful in the treatment of gastrointestinal disorders, particularly gastroduodenal conditions. The salts show the antisecretory activity associated with ranitidine together with antibacterial activity against Campylobacter pylori and they also possess cytoprotective properties.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.