Circulation-active fluoromethoxyphenyl dihydropyridine compounds

US5008279A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Gerhard Franckowiak · Wuppertal, DE
• Jurgen Stoltefuss · Haan, DE
• Martin Bechem · Wuppertal, DE
• Rainer Gross · Wuppertal, DE
• Michael Kayser · Hagen, DE
• Siegbert Hebisch · Wuppertal, DE
• Matthias Schramm · Cologne, DE

Key dates

• Filing date: Oct 27, 1988
• Grant date: Apr 16, 1991
• Expiry date: Oct 27, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/90
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Circulation-active fluoromethoxyphenyldihydropyridines of the formula ##STR1## in which X stands for hydrogen or fluorine and PA1 R stands for straight-chain, branched or cyclic alkyl or alkenyl having 2 to 12 carbon atoms which can be interrupted by 1 to 2 oxygen and/or sulphur atoms in the chain, and which can be monosubstituted or polysubstituted PA1 (a) by hydroxyl, aryl having 6 to 12 carbon atoms, aryloxy having 6 to 12 carbon atoms, where the aryl radical is again substituted by alkyl having up to 4 carbon atoms, alkoxy having up to 4 carbon atoms or halogen, the substituents being identical or different, or PA1 (b) by carboxyl, alkoxycarbonyl having up to 6 carbon atoms, pyridyl, piperidyl, pyrimidyl, acyloxy having up to 7 carbon atoms, sulphamoyl, carbamoyl, halogen or cyano, the substituents being identical or different, or PA1 (c) by an amino group, where the amino group can carry one or two identical or different substituents from the group consisting of alkyl having up to 6 carbon atoms, benzyl, phenyl or acyl having up to 7 carbon atoms, and salts thereof.