Process for the treatment of the skin to alleviate skin diseases arising from contact sensitization or irritation utilizing p-substituted phenoxy alkanols

US5008293A · kind A · utility

Inventor

• Frank Berger · Leutenbach, DE

Key dates

• Filing date: Jul 22, 1988
• Grant date: Apr 16, 1991
• Expiry date: Jul 22, 2008

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/085
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Skin diseases are treated by topical application of p-substituted phenoxy alkanols having the structure: ##STR1## in which: R.sub.1 substituted in ortho, meta or para position is selected from hydrogen, halogen, alkyl having from one to six carbon atoms, preferably para-chlorine or para-tertiary-butyl; and bivalent cycloalkylene condensed with the phenyl group at adjacent ring carbons thereof, such as in indane; PA0 R.sub.2 and R.sub.3 are hydrogen or hydroxyl and at least one of R.sub.2 and R.sub.3 is hydroxyl; and PA0 N.sub.1, n.sub.2 and n.sub.3 represent the number of CH.sub.2, CHR.sub.2 and CH.sub.2 groups, respectively, and are numbers within the range from 1 to 10. The topical application to the skin of these compounds jointly with an agent that causes irritation, inflammation or contact sensitization modifies and mitigates such irritation, inflammation and sensitization.