Production of human parathyroid hormone from microorganisms

US5010010A · kind A · utility

Assignee

• Selmer-Sande, A.S. · NO

Inventors

• Kaare M. Gautvik · Oslo, NO
• Peter Alestrom · Sandvika, NO
• Tordis B. Oven · Oslo, NO
• Odd Gabrielsen · Oslo, NO

Key dates

• Filing date: Aug 14, 1989
• Grant date: Apr 23, 1991
• Expiry date: Aug 14, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/02
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention provides recombinant plasmids containing in DNA sequences coding for human preproparathyroid hormone. The invention further provides microorganisms, for example E. coli, transformed by these plasmids. Finally, the invention also provides a plasmid for insertion into yeast and a transformed yeast in which the plasmid contains DNA coding for parathyroid hormone. Parathyroid hormone is then secreted by the transformed yeast.