1,7-fused 1H-indole-2-carboxylic acid-N-(1,4-benzodiazepin-3-yl)amides

US5010076A · kind A · utility

Assignee

• Kali-Chemie Pharma GmbH · DE

Inventors

• Harald Waldeck · Hannover, DE
• Werner Benson · Hannover, DE
• Horst Zeugner
• Klaus-Ullrich Wolf · Burgdorf, DE
• Peter-Colin Gregory · Hannover, DE
• Derk Hamminga · Weesp, NL
• Ineke van Wijngaarden · Weesp, NL

Key dates

• Filing date: Mar 7, 1990
• Grant date: Apr 23, 1991
• Expiry date: Mar 7, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds corresponding to the formula I ##STR1## in which R.sup.1 represents hydrogen, lower alkyl or cycloalkylalkyl with 4-7 carbon atoms, PA1 R.sup.2 represents hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl, and PA1 R.sup.3 represents hydrogen, halogen, lower alkyl or lower alkoxy, or PA1 R.sup.2 and R.sup.3 together denote an alkylenedioxy group, PA1 R.sup.4 represents cycloalkyl with 5 to 6 carbon atoms, thiophene or optionally substituted phenyl, PA1 R.sup.5 represents hydrogen or halogen, PA1 R.sup.6 represents hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl, and PA1 Z represents an alkylene chain with 2-4 carbon atoms, which can optionally be mono- or disubstituted by lower alkyl or onto which a 5-6-membered carbocyclic ring can optionally be fused, or represents an --X--CH.sub.2 --CH.sub.2 -- chain, which have pharmacologically valuable properties, are described, together with a method for their preparation.