Indolone derivatives, their preparation and their application in therapy
US5010079A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 2, 1989 |
| Grant date | Apr 23, 1991 |
| Priority date | — |
| Expiry date | Aug 2, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/34
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An indolone derivative is useful for the treatment of anxiety, depression and schizophrenia and is a 5HT.sub.1A agonist and 5HT.sub.2 antagonist, which is a compound of formula (I): ##STR1## in which R.sub.1 is a hydrogen or halogen atom or a (C.sub.1-4)alkyl radical, PA1 R.sub.2 is a hydrogen atom or a (C.sub.1-4)alkyl radical, PA1 R.sub.3 is a hydrogen atom, a (C.sub.1-4)alkyl radical or an S-(C.sub.1-4) alkyl radical; and PA1 R.sub.4 is a phenyl, chlorophenyl, naphthyl, 7-methoxy-1-naphthyl, 6-methoxy-1-indanyl, 2-methoxy-6-pyridyl, 3-methoxy-2-pyridyl, isoquinolyl, 7-methoxy-1-isoquinolyl, 7-methoxy-1,2,3,4-tetrahydro-1-naphthyl or 7-fluoro-1-naphthyl radical; PA1 or a pharmaceutically acceptable acid addition salt thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.