Imidazopyridines, compositions and use
US5010086A · kind A · utility
8Cited by
4References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 7, 1990 |
| Grant date | Apr 23, 1991 |
| Priority date | — |
| Expiry date | Aug 7, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones having an aryl or heteroaryl group in the 6-position, useful as phosphodiesterase inhibitors, are prepared by reacting a 2-amino-5-(aryl or heteroaryl)pyridine-3-carboxylic acid with diphenylphosphoryl azide. The compounds are of the formula ##STR1## where R.sub.1 and R.sub.3 are hydrogen or lower-alkyl, R.sub.5 is lower-alkyl or fluorinated lower-alkyl, and Ar is 4-or 3-pyridinyl, or N-oxides thereof, or phenyl or substituted phenyl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.