Discodermolide compounds, compositions containing same and method of preparation and use
US5010099A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 7, 1990 |
| Grant date | Apr 23, 1991 |
| Priority date | — |
| Expiry date | May 7, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D309/30
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel lactone compounds having remarkable immunomodulatory and antitumor activities, pharmaceutical compositions comprising such compounds, methods for the preparation of the novel compounds and compositions and methods of their use for therapeutic purposes are described. The new lactone compounds have the structure according to the formula: ##STR1## wherein: R=--H, --A, --CH.sub.2 --Q, --COA or --COZ, PA0 A=lower alkyl, PA0 Z=monocyclicaryl, PA0 Q=phenyl, tolyl or xylyl, PA0 X=--H, --A, --Z or --CH.sub.2 --Z, and PA0 Y=--H, --A, --Z, --CH.sub.2 --Z, --COA, --COZ, the acid-addition salts, the octahydro and 23,24-dihydro derivatives thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.