Preparation of phosphoric acid derivatives and intermediates

US5010193A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Fritz Maurer · Wuppertal, DE
• Reinhard Lantzsch · Leverkusen, DE
• Helmut Fiege · Leverkusen, DE
• Albert Schnatterer · Leverkusen, DE

Key dates

• Filing date: Dec 9, 1988
• Grant date: Apr 23, 1991
• Expiry date: Dec 9, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6512
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of a compound of the formula ##STR1## in which R is hydrogen, alkoxy, alkylamino, dialkylamino or an optionally substituted radical from the group consisting of alkyl, cycloalkyl, aralkyl and aryl, PA1 R.sup.1 is an optionally substituted radical from the group consisting of alkyl, alkoxy, alkylthio, mono- or dialkylamino and phenyl, PA1 R.sup.2 is optionally substituted alkyl, and PA1 Y is oxygen or sulphur, comprising (a1) reacting a compound of the formula ##STR2## with ##STR3## or with EQU R.sup.5 COOH in which PA1 R.sup.5 is R except for hydrogen, or equivalent, to produce ##STR4## oxidizing that compound or its salt to ##STR5## and phosphorylating. Several of the intermediates are new.