Method for the resolution of folinic acid
US5010194A · kind A · utility
18Cited by
4References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 7, 1989 |
| Grant date | Apr 23, 1991 |
| Priority date | — |
| Expiry date | Nov 7, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D475/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for the resolution of (6R,S)-folinates into their diastereomers, comprising adding a water-soluble alkali metal, ammonium or alkaline earth metal salt of an inorganic or organic acid to an aqueous solution of a salt of (6R,S)-folinic acid, removing by filtration the salt which separates out, which consists predominantly of the corresponding (6R)-folinates, and isolating the desired (6S)-folinate from the filtrate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.